The Temple Lung Center conducts one of the most comprehensive lung disease clinical trials programs in the country. Our advancements in basic, translational and clinical research are changing lung disease treatment. By pioneering effective therapies, we bring hope to patients with serious and debilitating lung diseases.
Review Our Open Clinical Trials
Alpa-1 Antitrypsin Deficiency
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema (ELEVAATE)
Asthma
Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States (PASSAGE)
NCT05329194
NCT05329194
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
NCT05097287
NCT05097287
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)
NCT05813288
NCT05813288
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Eosinophilic Asthma (EXHALE-4)
NCT05748600
NCT05748600
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/?Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
NCT06052267
NCT06052267
Pragmatic Open - Label Randomized Clinical Trial of FF/?UMEC/?VI vs Non-ellipta Usual Care ICS-LABA for Adult Participants With Uncontrolled Asthma
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study (REIMAGINE)
NCT06041386
NCT06041386
Bronchiectasis
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
Chronic Cough
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-1)
COPD
Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease
NCT05119556
NCT05119556
Immunological Basis for Mepolizumab Activity in COPD
NCT05320939
NCT05320939
STRIVE Post-Market Registry Study
NCT04302272
NCT04302272
Efficacy and Safety of Tozorakimab (MEDI3506) in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)
NCT05158387
NCT05158387
PH-COPD MK-5475-013 INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of MK-5475 (an Inhaled sGC Stimulator) in Adults With PH-COPD
NCT05612035
NCT05612035
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial) (DEPTH)
NCT05382208
NCT05382208
Inpatient Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
NCT06175065
NCT06175065
Hyperpolarized Xenon Functional Lung Imaging in COPD Patients Undergoing Targeted Lung Denervation
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
Biological Effects of Quercetin in COPD Phase II
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema (CONVERT_II)
A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS)
Interstitial Lung Disease (ILD)
Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis (TETON)
NCT04708782
NCT04708782
SSc-ILD A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease (BLISSc-ILD)
NCT05878717
NCT05878717
Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis (REVERT-IPF)
NCT05671835
NCT05671835
Study of Oral Epigallocatechin-3-gallate (EGCG) in IPF Patients (EGCG-101)
NCT05195918
NCT05195918
Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
A Study Evaluating the Safety and Efficacy of AP01 in Participants With Progressive Pulmonary Fibrosis (PPF)
NCT06329401
NCT06329401
Platform Clinical Study for Conquering Scleroderma (CONQUEST)
NCT06195072
A Study to Evaluate the Efficacy and Safety of GSK3915393 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
NCT06317285
Inpatient
Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)
Lung Cancer
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening (PROACT-LUNG)
Lung Transplant
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction (ROCKaspire)
Mesothelioma
National Mesothelioma Virtual Registry and Tissue Bank (U19)
Mycobacterium Avium Complex Disease
Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease (MAC2v3)
ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension (ICoN-1)
Pulmonary Embolism
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
NCT04798261
NCT04798261
The RESCUE II Study. The Bashir™ Endovascular Catheter (BEC)
Novel alpha2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial (NAIL-IT)
NCT05408546
NCT05408546
Sarcoidosis
A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
NCT05890729
Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis (KITE)
Other
American Lung Association (ALA) Lung Health Cohort
NCT04543461
NCT04543461